President Obama's foreign policy has employed a starkly different tone than George W. Bush's, emphasizing engagement and cooperation rather than go-it-alone confrontation. Even so, analysts of various political stripes hadn't seen many big differences on substance.

Until now.

Obama's decision Wednesday to scuttle a costly and technically challenged long-range missile-defense system in Europe marks his most significant reversal of a Bush foreign policy priority. It could change the dynamic of what has been an increasingly tense relationship between the U.S. and Russia, which viewed the Bush plans for missile defenses in Poland and the Czech Republic as a threat.

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