After Britain voted to leave the EU, Hillary Clinton issued a statement declaring that America’s “first task has to be to make sure that the economic uncertainty created by these events does not hurt working families here in America”.

While she leads Mr Trump in the polls and has an advantage due to support from demographic groups such as Hispanics and women, the comments underscored that she cannot underestimate the populist mood that has overturned conventional wisdom at every twist and turn of the 2016 White House race.

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